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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

AFI TV Programs of the Year
预测人士期望2014年能够成为经济实现突破的一年。但经济能否最终摆脱低迷的增长,还要取决于几个因素出现与此轮复苏刚开始时不一样的表现。以下是其中的几个关键因素:

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

Stanford Graduate School of Business in California rises from fifth place in 2016 to second, a position it last held in 2014. The Wharton School of the University of Pennsylvania is in third place.
Other European cities have seen increases in costs, pushing them up the rankings. London rose five points, bringing it into the top 10.

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
From the themed collection: 8个词,数尽中国家具8年沉浮
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

4. Stop eating, gotta get those cheekbone sharp enough to cut butter.

Graphical abstract: Soft matter science and the COVID-19 pandemic
From the themed collection: 解读2015年家具行业十大热点问题
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

The import side of the equation fared worse in both renminbi- and dollar-terms.

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

《初来乍到》(Fresh off the Boat),ABC,2月4日播出。这部喜剧是根据大厨与美食、旅游真人秀主持人黄颐铭的回忆录改编的,讲述20世纪90年代中期的佛罗里达,一个华裔美国家庭克服文化冲突,努力适应美国生活的故事。哈德逊·杨(Hudson Yang)饰演迷恋嘻哈乐的11岁男孩艾迪,在《采访》(The Interview)中饰演金正恩的兰道尔·朴(Randall Park)饰演他的父亲,一位郊区牛排餐厅骄傲的店主。
[t?ek]
2016年度的《胡润百富榜》显示,姚振华的净财富去年涨了逾8倍,至172亿美元,他也因此成为中国的第四大富豪。去年他的排名是第204位。
A new paper on the Dutch debacle, coauthored by Peter Koudijs at Stanford Graduate School of Business, turns up modern-day lessons about the not-so-scientific ways in which personal experience rather than market information can determine optimism, pessimism, and access to credit.

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
From the themed collection: “花式”转移婚内财产有法可究
Perspective

Trends and targets in antiviral phototherapy

2.德语:增长了22.2%
Maria Rios
The survey discusses projections for going forward: "The cost of living is always changing and there are already indications of further changes that are set to take place during the coming year."
Then in 2011, her mother Melissa was signed up to appeared as part of the Lifetime reality series Dance Moms.

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

n. 商业广告

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

在主持过去年的奥斯卡颁奖典礼、之前的格莱美奖及艾美奖之后,她无疑是这个角色的最佳选择。

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
From the themed collection: 智能家居产业将迎爆发期
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

A thin line separates confidence and delusion, and Kobe Bryant is straddling it. It's the only conclusion one could reach after judging the Los Angeles Lakers star's comments Tuesday after he tied the worst shooting performance of his career in any game in which he attempted at least five shots.
Have any franchise-leading duo reinvented themselves as spectacularly as Twilight’s Kristen Stewart and Robert Pattinson? Both have become art-house mainstays. Pattinson’s latest Good Time, keeps going his recent pattern of looking fairly unrecognisable. After he transformed himself with shaggy beard and spectacles in The Lost City of Z he now has bleach-blond hair as a bank robber who tries to pull off the perfect heist in New York City, only to get his younger brother (Ben Safdie), who suffers from a developmental disability, arrested for the crime. He tries to use the money he stole to post his brother’s bail, but complications ensue. Many complications. In addition to appearing as the younger brother, Safdie co-directs the film with his own brother Josh Safdie, and Good Time was selected to compete for the Palme d’Or at Cannes. Released November 3 in Japan, November 17 in the UK and Ireland and November 23 in Greece. (Credit: A24)

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
From the themed collection: 2014年家居行业销售渠道下沉
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

节目12 小品《大城小事》,艾伦 王宁 常远
At the same time, entries for gout jumped by just over a third – a disease associated with "ease and comfort" in Victorian London, now more likely to be linked with deprivation and lack of work.

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

In addition to a large, educated workforce to choose from, companies are also attracted to Arizona’s pro-business regulatory climate, which ranks No. 13 in the Mercatus Center’s Freedom in the 50 States. The study cites Arizona’s right-to-work law, liability laws and eminent domain reform.
在过去三年失业率已从8.6%降至5.8%,但是包括美联储,几乎没有人认为劳动力市场现在是真的健康。

Graphical abstract: Diagnostic technologies for COVID-19: a review
From the themed collection: 市场淡季来临,陶瓷指数下跌
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

vt. 记载,(用文件
SplashData公司建议,使用榜单上出现的密码的用户和公司赶快修改自己的密码。SplashData公司警告称,用数字代替字母的常见密码,像“dr4mat1c”,也很容易遭到破解,因为现在密码入侵者的科技手段也越来越高端了。
会。供应中断和地缘政治风险因素很可能会持续出现,同时伴随着全球生产商限产。但价格能否保持在70美元或以上水平取决于:在美国页岩油供应不断增长的情况下,俄罗斯是否愿意继续支持沙特阿拉伯牵头的限产努力。参与限产的其他国家也需要继续坚定地遵守协议——随着各国政府受益于油价上涨,继续遵守协议的动力将越来越小。
The 500 brands come from 28 different countries, among which nearly half, 227, are from the US.

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

这名43岁的女子被判处为期12个月的行为考察,并且不得再次拥有宠物。

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

Red ones mean passion and romance, yellow ones speak of friendship, and pink can express your thanks.红玫瑰代表热情和浪漫,黄玫瑰象征友谊,粉玫瑰则表达谢意。If
《巴克斯托姆》(Backstrom),Fox,1月22日播出。去年,福克斯推出根据一部澳大利亚电视剧《法庭浪子》(Rake),由格雷格·金尼尔(Greg Kinnear)主演,讲述一个自毁律师的故事。那部剧没成功,但现在Fox又试着推出了一部根据瑞典系列小说改编的自毁侦探的故事,由《办公室》(The Office)男星雷恩·威尔森(Rainn Wilson)主演。这部剧由Fox的系列剧《识骨寻踪》(Bones)的编剧哈特·汉森(Hart Hanson)主创,但在试播集里,威尔森饰演的巴克斯托姆看上去更像豪斯医生(House),而不像《识骨寻踪》里的角色。

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
From the themed collection: 90后成返乡置业主力
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

在定制课程排行榜上,排在第二名瑞士洛桑国际管理发展学院之后的是杜克企业教育学院(Duke Corporate Education)。这是这所美国学校连续第3年位列第三。该校在2014年连续第12年占据定制课程排行榜榜首位置,创下纪录。

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
From the themed collection: 2016年45家陶企在央视砸了3亿多元
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

Siemens broke records last year by winning two awards for renaming its healthcare business Healthineers. Not only does it land the Martin Lukes prize for the worst combination of two words, the accompanying video, featuring a singing CEO and writhing spandex-clad employees, wins a gold medal for most embarrassing company song of all time.

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

China's Internet celebrities are estimated to create a whopping 58 billion yuan ($8.7 billion) market in 2016, far surpassing the 44 billion yuan in box office sales generated last year, according to an industry report.
“有个女员工说自己去买靴子,但再也没露过面。”
You know the old guy who's been at the company forever and still can't figure out email? If you don't get up to speed on social media in 2014, you'll be that guy. Compared to last year, there are 13 times as many jobs advertised on Indeed.com that mention the use of social media. "We are seeing an increased demand for social savvy candidates across the business -- from human resources to product to customer service, " Amy Crow, Indeed's communication director told Quartz earlier this year. Not only are departments like marketing, sales, and customer service expected to be on Twitter (TWTR) and Facebook, teams as diverse as R&D, logistics, and HR are increasingly using internal networks like Yammer to streamline operations. Social media has grown so critical to the workplace, in fact, that major universities are beginning to offer certificate programs for socially inept corporate types to get up to speed.
失业率减幅在2015年的下降得可能不会那样的迅速,据经济学家所言,特别是如果更多的人进入劳动力市场由于更容易找到工作。尽管如此和2014年相似的大量招聘和录用将会使低的失业率数据显得更加的可信。

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

How the longer maternity leave policy is implemented is up to local governments to decide. Specific and legally-binding measures should be worked out at the national level to ensure the policy is carried out and properly enforced to ensure that women are not discriminated against by employers obsessed with minimizing their labor costs.
While Jodie Foster used to opt for the bathroom – “they looked good with the faucets” – she has since moved the two she won for The Accused and Silence of the Lambs to a much more orthodox spot: a trophy case.
此外,他们在毕业后改行的可能性更小。只有30%改行,而全日制MBA学员却有近三分之二改行。
“Through the second half of the 20th century we had this big dispersion of trade and economic activity around the world. All this specialisation meant exports rose faster than GDP,” Mr Williams says.
BrandZ表示,中国科技集团华为(Huawei)已从苹果(Apple)和三星(Samsung)手中夺取市场份额。

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

Of course, the recovery of the job market has been, and probably will remain, incremental. Job growth needs to be much stronger to actually make a big dent in unemployment, which remains high at 7.9%, though down from 10% three years ago.[qh]
To provide assistance to these laid-off workers will continue to be our priority in cutting overcapacity and pursuing the supply-side structural reform.

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
From the themed collection: 是谁制造了房租上涨 原因何在
Critical Review

The role of biosensors in the detection of emerging infectious diseases

就算利润率更低(比如40%),并且替代率为1/3(即全价iPhone的客户流失三分之一),低价iPhone也能提高苹果的营收和毛利润(见上表)。

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

A Method to the Madness

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

有些人则特地请人代劳:
今年六月,谷歌宣布与时尚设计师黛安o冯o芙丝汀宝合作,携手推出新款谷歌眼镜。这个举措凸显了硅谷当下的策略:招募时尚精英,赋予可穿戴设备以时尚内涵。
智能冰箱
《纽约时报》记者詹姆斯?格尔曼追踪报道了一群科学家,他们试图找到将狼与狗区分开来的基因。为了进行科学研究,饲养小狼崽的人必须每周7天、每天24小时和它们在一起,使它们能够适应社会化,以便进行科学研究。尽管这些幼崽看起来很可爱,它们最终还是会成长为掠食性的狼,而不是人类的忠实伙伴。研究人员希望他们的工作将有助于揭示,究竟是什么因素在历史上让一部分狼演化成人类熟悉的狗。

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

Beloved TV show characters enter our lives as friends and impact us in crazy ways. They can make us laugh until our sides hurt, cry when things don't go well for them, and call in sick to work when we just can't stop watching and must know what happens. But through it all, we love them. And yet, there's so much that the audience will never know. Some TV shows have dark secrets. Some almost didn't exist at all. Here are some behind the scenes stories of your favorite TV shows.
Summly was backed by Horizons Ventures, the venture capital arm of Hong Kong billionaire Li Ka-shing, and other tech and media names including actors Ashton Kutcher and Stephen Fry, Spotify’s Shakil Khan and Zynga’s Mark Pincus .
In his report of Global Market of Industrial Robots, Junji Tsuda, president of International Federation of Robotics (IFR), noted that about 387,000 industrial robots were sold in 2017 worldwide, up 31% year-on-year, creating $50 billion in revenue, with China as one of key drivers behind the strong growth.
How much time? And to what extent will bitcoin, in seeking wide adoption as a currency and as a protocol for new applications, face the hurdle of mainstream consumers’ lack of understanding? Adam Ludwin suggests that people don’t need to understand how the technology works to appreciate it. “It has the quality of early Internet,” he says. “People don’t actually know anything about how it works, but they don’t need to know, or care. They just know they turn their computer on and can check email.”

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

现在达洛伊西奥还不负责管理他的收入。他坚称说,我太年轻了,还不懂如何发挥其价值。我没有房贷,我才17。对我来说100英镑就是个大数目了,这就是我对钱的大致概念。尽管他无法对Summly的售价置评,但当我逼问他未来打算如何支配的时候,他说他在考虑以后也许可以用所发之财来做一名天使投资人。在他身边,似乎没人觉得这份钱会毁掉他或者他会挥霍钱财浪费人生。戴安娜说,孩子很踏实,很有冲劲儿,他不会停止奋斗的。
Inventors Bryan Carpenter and Bland Hoke were inspired by their passion for the outdoors, and decided to come up with a creative way to bring their hammocks everywhere they go.

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

create增长,产生+ive →有创造性的
In addition, the last quarter of 2016 marked the first time that Huawei achieved a double-digit global market share.
请尊重一下那些支持你的人以及节目主持人,能在访谈开始前把口香糖吐了吗?
人们最为关心的问题是,2015年石油价格将何去何从?石油目前的低价位是不可持续的。许多产油成本较高的企业和地区都处于亏损状态。短期内这种状况也许还可以应付,但中长期来看,石油公司将被迫退出市场,进而带动油价上升。然而,最重要的问题在于:石油价格何时上涨,以及涨幅能有多大?
Equally, a three-week interning stint at PwC in the school summer holidays gave her the chance to sample life in a professional services firm. “I didn’t think I would get a place on [PwC’s programme] as I had no business experience,” she says.

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

China's National Bureau of Statistics said its property prices index for November showed that new home prices fell 3.7 per cent from a year ago, the third straight annual decline following readings of -2.6 per cent in October and -1.3 per cent in September.
But the demagogue’s exploitation of such grievances threatens democracy.
senior

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

谎言4:太感谢了!我很喜欢!说谎原因:告诉别人他们送的礼物一团糟会让我看起来像是冷血的混蛋。
The number of such applications in Beijing last year increased 426% from that of 2015.

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

单词extend 联想记忆:
它是一种受谅解和制度制约的权力争斗。
'If global demand picks up in the developed world, and you combine that with the growth in the emerging economies, I think the market is going to get tight,' he said, which means those mighty peaks could return to the oil-price graph.

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

保罗麦·卡特尼(是的,还有Wings乐队)凭着邦德电影《生死关头》的主题曲闯出了一片新天地。007系列电影做出了一些更换,灵魂人物邦德改由罗杰·摩尔出演,因此影片选取了20世纪70年代的音乐声作为主题曲。这是一首令人异常兴奋的歌,旋律变化无常、旋转跳跃、跌宕起伏,听众根本没有机会抓住歌曲要表达的东西,令人震撼。
技术在法律界并不是一个新现象——许多律所已经与人工智能和机器学习企业建立了合作伙伴关系,有些律所还建立了自己的“孵化器”,或者投资了法律科技初创公司。但这一趋势已经达到临界水平,并将在2018年急剧加速。
联想记忆

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

价格:197.5万美元(约合人民币1226万元)

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

如果没有别的,很明显,夏天交易期并不代表NBA赛季的停止,它只是换了个档而已。

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

“我去的每一个地方,都发现企业主对未来的需求量有一个很好的预期,” Gus Faucher PNC金融服务机构的资深经济学家称。“商人必须提高薪酬来吸引更多的劳动力或者保留原有的工人”。
4. No talking during the game, wait for half-time or end of the game.

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

玛戈特·瓦尔斯特伦(Margot Wallstrom)
China’s trade surplus grew to Rmb496.2bn last month from Rmb382.1bn in December. Economists expected it to inch higher to Rmb389bn. In dollar terms, China’s trade surplus rose to $63.29bn from $60.09 in December and versus expectations of $60.6bn.
adj. 高品质的
胡润估计,中国内地目前有594位身家十亿美元以上的富豪,在香港、台湾和澳门还有94位,而美国仅有535位。

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
From the themed collection: 2016年卫浴洁具十大品牌排行榜
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

德里克·罗斯
艾玛·汤普森曾因影片《霍华德庄园》(Howards End)以及《理智与情感》(Sense and Sensibility)两次获得奥斯卡金像奖,而她把小金人放在洗手间这一做法也广为人知,她说:“放在其他地方都显得格格不入,它们太大了,又金光闪闪。”而艾玛并不是唯一一个这样做的人,苏珊·萨兰登(Susan Sarandon)、莱昂纳尔·里奇(Lionel Richie)以及肖恩·康纳利(Sean Connery)都称自己把小金人放在浴室等地方。

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

乌拉圭之所以取得成功,不仅仅是因为它对足球的激情,还因为其早期文化的包容性。在1950年世界杯上,当时其邻国巴西仍然对黑人球员心存怀疑,乌拉圭队却以拥有一位黑人队长、杰出的巴雷拉而感到自豪。此外,乌拉圭在世界杯成型期的胜利造就了延续至今的血统,它的很多球员如今都在海外的一些世界豪门俱乐部踢球,如利物浦的苏亚雷斯和巴黎圣日耳曼的卡瓦尼。
If you are working your butt off and not getting paid enough to pay your bills, you might be overqualified and underpaid for your position. Go find a job that pays what you deserve.

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

Finding the skill sets and attitudes that support the culture of the brand you want to promote will foster innovation and enhance your reputation. Include folks from outside the company for the people you rely on. That will start a free marketing chain reaction that can build confidence and revenue.

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

3. “Bridge of Spies” Years ago, Steven Spielberg entered the ranks of Pantheon Directors, to borrow the most exalted category in Andrew Sarris’s taxonomic “The American Cinema” — and there he remains.
Chris Paul
《大城小妞》(Broad City),Comedy Central,1月14日播出。伊拉纳·格雷泽(Ilana Glazer)与艾比·雅克布逊(Abbi Jacobson)带着第二季回归了,它讽刺了纽约那些大材小用而又自恋的人们生活中的故作姿态、妥协与纯粹粗俗。
经济衰退可能已有所好转,但是距离就业市场的复苏还有很长一段路要走。并且专家也声称情况在好转之前可能先会恶化。

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

深入推进“互联网+”行动和国家大数据战略;
May the bright and festive glow of New Year candle warm the days all the year through. Hoping you will have a wonderful time enjoying New Year that is happy in every way.

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

[m?'r?liti]
然而,他认为,“在解释新兴市场危机的发生率时,美国的货币政策往往与新兴市场国内因素同样重要——如果不是更重要的话。”
万分沮丧之下,他发明了可以允许自拍的东西:他称之为"伸缩杆"。因为智能手机还没发明出来,所以,连接在自拍杆末端的是一个微型相机。在杆的前端有一面小镜子,方便使用者调整他们在相机里的姿态。他在1983年为"伸缩杆"申请了专利。虽然自拍杆进行了大量生产出售,却属商业败笔——相片的质量比较差。另外,以前的研究表明,那时的女士会因自己有自拍的想法而感到尴尬。在2000年,自拍杆被韦恩·弗洛姆(Wayne Fromm)重新发明,那时,上田宏的"伸缩杆"专利期尚有三年。弗洛姆称他的自拍杆为"快捷豆荚"。他认为他才是当今自拍杆的发明者,甚至起诉其他自拍杆生产者。当被问到上田宏的自拍杆时,弗洛姆评论说它们是"先前的艺术"。

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

(传说中的中心对称!!!!)不过Illuminati的对称文已经遗失,下面的对称文是Dan Brown在写《天使与魔鬼》的时候找朋友设计的。 就《天使与魔鬼》一书描述,尽管很多人怀疑该组织的真实性,但光照派的确存在,至今如此,并且已经渗入了当今各个领域,尤其是很多共济会成员都在其中。
美国退伍军人节也跟世界其他国家纪年第一次世界大战的节日重合,其中包括英国和英联邦国家澳大利亚以及加拿大的纪念日。
3.数学家

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

你或许要很长时间才能实现工作与生活的平衡,但努力遵守这个清单,并将其作为创业的目标,将会产生不一样的效果。创业者如何看待所取得的进步?以及一家公司多快才能实现正常运营和实现收支平衡?遵循这些建议,你很快就能找到答案。
近年来,大多数发达国家的排放量一直在逐步下降,这部分是因为不景气的经济形势,同时也是因为日益加强的气候政策。2013年,由28个国家组成的欧洲联盟(European Union)的排放量下降了1.8%,虽然德国和波兰等几个国家的耗煤量出现增加。英国、意大利和西班牙的排放量显著下降。

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
From the themed collection: 租房分期,真的如此美好吗?
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

Mr Cook’s decision to expand its cash return programme of dividends and share buybacks helped to defuse the situation with the activists, returning $94bn to date. In the end, he stared down the challenge just long enough for the next wave of iPhone growth to hit and new products to emerge from Sir Jonathan Ive’s workshop.
此外,由于该机构的一些业务涉及为政府提供教育方面的建议,此类员工的专长是很宝贵的。
Traditionally Chinese universities scored less well in international ranking tables compared to US and European incumbents in levels of teaching and research.

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

For parents, it is always a struggle to carry their children all day long, especially when they’re getting bigger and heavier.
卡尔还表示:“就算没有厄尔尼诺现象,去年气温也有可能创纪录,但厄尔尼诺现象让高温更加极端。”

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

Chinese property magnate Wang Jianlin has defended his crown as the country's richest man, according to the annual Hurun rich list, fending off Alibaba Group Holding Ltd (BABA.N) founder Jack Ma and new players on the block like Baoneng's Yao Zhenhua.
目前还不清楚拉格菲尔德离世之后将由谁来照顾邱佩特。
'It is most probably from a mine in South Africa known as Premier mine and now as Cullinan, where most of the blue diamonds are from. Probably in the last 30 years,' Mr Lunel said.

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

n. 病毒,病原体

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

The highest scoring tournament: 1994 in theUnited Stateswhen 24 teams averaged 2.97 over 52 matches.
polish

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

除了查阅综合榜单,未来的国际学生还可以缩小搜索范围,浏览某地区和某国家大学排行。这些排名仅由学校在综合榜单中的表现决定。
减薪前奥朗德的年收入为25.56万欧元(约合27万4522美元),仅次于美国总统奥巴马。但现在他的年收入仅为19.87万美元。众所周知,他的御用理发师年收入高达13.2万美元。

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

老虎要入眠,鸟儿要降落;
6.Belize

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

当我想要对一个机会大声喊“No”时,这往往是个信号,提醒我还有一个答案或许该是“Yes”。如此一来,我会深呼吸一下,然后尽量客观地分析现状。
5. Emma Stone

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

An international medical journal's retraction of 107 research papers from China, many of them by clinical doctors, has reignited concerns over academic credibility in the country.

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

But the developments also point to the vast gap in the use of such cases between the US and EU, where a debate is under way over whether to grant China “market economy” status in the World Trade Organisation, a concession that would make it even harder to bring anti-dumping cases.
Making the cut for the first time, Gigi, 22, and Bella Hadid, 21, are ranked at number five and number nine respectively, with the former making $9.5 million and the younger sibling taking in $6 million.
Lecent去世当月,警方并未透露是她自己无意间扣动扳机还是被屋内的其他人射中。
然后,事情峰回路转。库迪斯和沃斯发现,荷兰贷款机构对于Seppenwolde的倒闭做出的反应截然不同。那些曾经贷款给Seppenwolde、但一毛钱也没损失的贷款机构变得越发悲观,要求所有新借款人都提供更多的“折幅”。而那些从未贷款给Seppenwolde、因而躲过一劫的贷款机构则根本没有提高要求。事实上,这些贷款机构可能还略略降低了对借款人的“折幅”要求,至少表明他们和过去一样乐观。

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

[.h?spi't?liti]

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
From the themed collection: 评论:谨防房价未跌物价先涨
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

获奖者:剑桥公爵和剑桥公爵夫人殿下(共同获奖)
Inflation (and deflation) won't rear its ugly head Surging oil production — along with slower global growth — has caused the price of petroleum to collapse from more than $100 a barrel last summer to barely $50 a barrel at the end of 2014. The effect has been to reverse an uptick in U.S. inflation earlier in the year.
UPON HEARING, IN MARCH of this year, reports that a 17-year-old schoolboy had sold a piece of software to Yahoo! for $30 million, you might well have entertained a few preconceived notions about what sort of child this must be. A geeky specimen, no doubt. A savant with zero interests outside writing lines of code. A twitchy creature, prone to mumbling, averse to eye contact.

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

美国科学家Craig Bennett,Abigail Baird,Michael Miller,和George Wolford被授予搞笑神经科学奖,以奖励其在脑科学研究方面的贡献。他们的研究显示,利用复杂的设备加上简单的统计学方法,你几乎可以在任何地方得出有意义的脑活动研究结果——甚至是在一条死去的鱼身上也是如此!
There are 27 companies that are dropped from the list this year, including AT&T, IBM, Siemens and Xerox.

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

Local champions
该书作者马丁輠祹(Martin Ford)周二在纽约的颁奖典礼上获得了英国《金融时报》和麦肯锡(McKinsey & Company)颁发的3万英镑奖金。

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

风水学。风水学也是可以帮助我们很好地布置办公桌的好帮手,千万不要把自己的桌子摆在一边靠着墙,背朝着门的方向。

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
From the themed collection: 铝门窗行业未来发展十大趋势解析
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

In the field of the best 85 business schools in Europe, HEC Paris remains in second place behind LBS, while Insead, the international school based in Fontainebleau, France, climbs two places to third.
特斯拉是一款富人车。在均价85,000美元的水平线上,可以说买特斯拉的人没人会在意汽油钱。特斯拉在续航里程上的短板,也说明了它绝对不会是车主家里的唯一一辆车。如果这些人的新鲜劲儿过去了,特斯拉的订单储备就会缩水,也会像其它厂商一样需要为销量打拼。
More than an hour into Apple’s annual shareholder meeting in February, Tim Cook had patiently fielded questions ranging from its plans for the television market to what he thought of Google Glass. But when one audience member tried to push Apple’s chief executive on the profitability of Apple’s various environmental initiatives, such as its solar-powered data centre, Mr Cook snapped.

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
From the themed collection: 佛山建筑陶瓷企业抱团保价求发展
Paper

Length-scale dependence of protein hydration-shell density

Tencent, with an estimated value of $44.7 billion, was crowned this year's Most Valuable Chinese brand on a list released by the Hurun Institute on Thursday, marking the second time in a row it came up on top.
明年,市长的保障性住房计划将初具规模,该计划要求在未来十年里,修建或保留20万套保障性住房。这一目标的实现取决于一项政策,它要求开发商通过修建保障性住房,来换取在市政府重新规划的社区修建更高、更密集楼盘的资格。至于政府将会如何在这项提案的雏形上添砖加瓦,开发商和保障房倡导者们都在拭目以待。
金发女郎乐队《花粉传播者》
米兰达·兰伯特,《浴室水槽》(Bathroom Sink),RCA Nashville

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

如果Lloyd Grossman有机会进入奥斯卡得主们的家中,他将会在很多不同的地方看到他们各自的小金人,从高级房产的壁炉台到积尘良久的壁橱深处,都可能看到它的身影。
4.菲亚特 品牌喜爱度:-7%/排名:85

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

斯托特说,对于2015年破纪录的气温来说,当前的厄尔尼诺现象可能只负有10%的责任。厄尔尼诺现象令太平洋海水变暖,是自然界一种经常性现象。
如果你热爱生存,那么脑死亡是一件不美好的事。而且,如果你想用空闲的大脑来替换,那你是绝对找不到的。当然,也许有一天,我们能将大脑放入头骨中,但是大脑跟别的器官不同。它装有你所有的思想和记忆。人们能在你头里放一个新的大脑,但是你还是不存在,所以人造大脑这种想法看起来很荒谬。
talented

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
From the themed collection: 市管公积金月缴上限涨548元
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One of the two artefacts which has a metal ring attach to it was discovered in the Yizheng city in western Jiangsu.
Writing for a Variety Special: Patton Oswalt, “Patton Oswalt: Talking for Clapping”

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